Premium
Langerhans cells of human skin are the natural antigen‐presenting cells for CD1c antigen presentation
Author(s) -
Sieling Peter Allan,
Becker Todd,
Ochoa MariaTeresa,
Legaspi Annaliza,
Rea Thomas,
Modlin Robert
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1068.10
Subject(s) - cd1 , antigen presentation , antigen , antigen presenting cell , epidermis (zoology) , mhc class ii , immunology , biology , langerhans cell , monocyte , major histocompatibility complex , t cell , cytotoxic t cell , mhc class i , population , natural killer t cell , microbiology and biotechnology , immune system , in vitro , cd8 , medicine , biochemistry , anatomy , environmental health
CD1 proteins are a family of MHC‐like polypeptides that are distinguished from MHC proteins through their presentation of lipids rather than peptides to T cells. Although the expression of CD1 proteins resembles that of MHC class II, i.e. mostly on professional antigen presenting cells, the natural antigen presenting cell population(s) for human CD1c‐restricted T cells have not been identified. CD1c‐restricted T cells derived from leprosy patients were potently activated by LCs derived from the epidermis of healthy donors and their in vitro‐derived counterparts, LC‐like dendritic cells (LC‐like DCs). In contrast, although DCs isolated from the dermis of healthy skin and monocyte‐derived DCs presented antigen to CD1c‐restricted T cells, their level of antigen presentation was greater than two‐fold less effective than LCs. Our data indicate that Langerhans cells from normal human epidermis are natural antigen presenting cells for CD1c‐restricted T cells and suggest that LCs are programmed for CD1c antigen presentation to T cells against cutaneous pathogens such as M. leprae .s