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Antibacterial Activity of New Coumarins
Author(s) -
Govori Sevdije R.,
Spahiu Sabrije,
Haziri Arben
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1061.6
Subject(s) - escherichia coli , coumarin , staphylococcus aureus , antibacterial activity , chemistry , pseudomonas aeruginosa , nucleophilic substitution , minimum inhibitory concentration , bacteria , antimicrobial , medicinal chemistry , organic chemistry , biochemistry , biology , genetics , gene
4‐(4‐Bromo‐thiazol‐2‐ylamino)‐3‐coumarincarbaldehyde (1), 4‐(4‐Methoxy‐benzothiazol‐2‐ylamino)‐3‐coumarincarbaldehyde (2) and 4‐(2‐Chloro‐6,7‐dimethoxy‐quinazolin‐4‐ylamino)‐3‐coumarincarbaldehyde (3) are synthesized in very good yields, by nucleophilic substitution with aminoheteroaryl derivatives on 4‐chloro‐3‐carbaldehyde. The antibacterial activity of coumarin was tested against: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853. The compounds showed strong to moderate activity in reducing the microbial growth. The inhibitory effects of compounds were affected by their substitution patterns. All compounds showed the most effective antibacterial activity against Escherichia coli ATCC 25922.