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Cardiolipin Modulation in the Mammalian Heart
Author(s) -
Bick Diane,
Holmes Michael,
Sparagna Genevieve
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1017.8
Subject(s) - cardiolipin , mitochondrion , phospholipid , enzyme , biochemistry , inner mitochondrial membrane , chemistry , oxidative phosphorylation , metabolism , biology , medicine , membrane
Cardiolipin (CL) is a phospholipid found in the inner mitochondrial membrane. It is essential for the optimal function of many of the protein components of the mitochondrial electron transport chain, metabolism and programmed cell death. CL has four fatty acyl chains. In the normal adult mammalian heart these fatty acyl chains are predominantly linoleate (18:2), making the dominant species tetralinoleoyl CL ((18:2) 4 CL). Research indicates that the composition of the CL acyl chains is altered in disease states associated with mitochondrial dysfunction like heart disease, ischemia and oxidative stress. The specificity of the CL side chain composition is not a result of specificity in CL biosynthesis. Specificity is determined by a remodeling process by which is either deacylation/reacylation or transacylated by enzymes using other phospholipids as acyl donors. We hypothesized that observed changes in cardiac cardiolipin levels may be the result of altered expression of enzymes in involved in the synthesis and/or remodeling of cardiolipin. Quantitative RT‐PCR analysis of several of these genes indicates a significant change in expression as a result of changes in diet and induced heart failure, conditions where changes in CL composition are documented. Supported by NIH HL072770 to DB