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Sex Differences in Injury from Acute Myocardial Ischemia‐Reperfusion are Intact in Rats Selectively Bred for High and Low Capacity Running (HCR/LCR).
Author(s) -
Fontenot Elizabeth,
Koch Lauren G,
Britton Steven L,
Lust Robert M
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb98-a
Subject(s) - medicine , cardioprotection , ischemia , cardiology , reperfusion injury , myocardial infarction , diabetes mellitus , infarction , endocrinology
PURPOSE: Female rodents usually have smaller infarctions than males. LCR males are obesity and diabetes prone, larger, and heavier when compared to HCR males. Size disparities between the HCR/LCR are smaller in the females. We have reported that infarct size was not different in HCR/LCR male rats following acute regional ischemia reperfusion injury (ARIRI). These studies were designed to determine whether sex differences in infarct size were preserved with phenotypic selection. METHODS: ARIRI was induced by a 30 min ligation of the left anterior descending coronary artery, followed by 2 hr of reperfusion. The infarct size was determined by 2, 3, 5‐triphenyltetrazolium chloride staining, and normalized to area at risk. RESULTS: A strain difference in infarct size was not evident in either the male (HCR (n = 7), 42.70 ± 7.05; LCR (n = 7), 44.66 ± 8.95) or female (HCR (n = 5), 32.62 ± 4.76; LCR (n = 8), 31.89 ± 7.20). Females had significantly smaller infarcts (p< 0.05) compared to their male counterpart, regardless of strain. CONCLUSIONS: In these models, the potential to exercise does not alter myocardial injury induced by ARIRI, suggesting that active exercise might be more important in cardioprotection than simply the capacity to exercise. These results do suggest that the phenotypic selection based on endurance running preserves sex differences in ischemia‐reperfusion injury.