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Complex Carbohydrate Diet Prevents Cardiac Growth and Preserves Contractile Function in a Model of Mild Hypertrophy
Author(s) -
Chess David Joseph,
Hoit Brian,
Stanley William
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb93-c
Subject(s) - pressure overload , muscle hypertrophy , medicine , cardiology , left ventricular hypertrophy , constriction , endocrinology , diabetes mellitus , cardiac function curve , cardiac hypertrophy , blood pressure , heart failure
Despite major medical advances, diet presents the greatest therapeutic potential for the treatment of cardiovascular disease (CVD). This study investigated the effect of diet on the development of left ventricular hypertrophy (LVH) in response to pressure overload. C57BL/6J mice, aged 7 weeks, underwent either transverse aortic constriction (TAC) or sham surgery (n = 12/group). Then, animals were fed four different diets: control, high fat, high starch, and high fructose. Left ventricular structure and function were assessed by echocardiography before and 5 and 16 weeks after surgery. As seen in the table below, banded animals fed the control or high fat diet had the greatest heart weight to body weight ratio (HW:BW). The high starch diet, in contrast, improved contractile function in the setting of pressure overload.