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The Affect of Heart Rate on Arterial Distensibility in Young Healthy Adults
Author(s) -
Hunt Brian E.,
Matos Manuel D.,
Renzi Christopher,
Mack Martin
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb91-a
Subject(s) - medicine , cardiology , blood pressure , heart rate , applanation tonometry , supine position , pulse pressure , arterial stiffness , diastole
Heart rate has been reported to reduce arterial distensibility as determined by ultrasonography and arterial pressure in both animals and older humans with cardiovascular disease. However, indices of arterial distensibility derived from pulse waveform analysis (applanation tonometry) are reported to increase or be unchanged with heart rate in heart disease patients. The purpose of this study was to directly compare ultrasound and tonometry derived indices of arterial distensibility in central (carotid) and peripheral (radial) arteries during atrial pacing in young, healthy adults. Heart rate (ECG), blood pressure (Finometer and applanation tonometer), and arterial diameter (ultrasonography) were measured in young healthy men (n=4) and women (n=2) during 90 seconds of unpaced (UP) supine rest, and tranesophageal atrial pacing at 90(P90) and 120 (P120) bts/min. Ultrasound derived distensibility (Dist US ) was estimated as: (Systolic Diameter – Diastolic Diameter)/ (SBP – DBP)/Diastolic Diameter. Tonometry derived augmentation index (AI) was estimated from the tonometry waveform as: (Peak Systolic Pressure – Pressure Inflection Point)/Pulse Pressure x 100. As heart rate increased Dist US declined in both carotid (UP: 0.40±0.07; P90: 0.29±0.06; P120: 0.20±0.06 cm2/dyne‐6) and radial arteries (UP: 0.012±0.003; P90: 0.009±0.001; P120: 0.006±0.001 cm2/dyne‐6). However, AI decreased in both carotid (UP: 82±4%; P90: 85±1%; P120: 70±6%) and radial arteries (UP: 50±5%; P90: 44±5%; P120: 31±6%). This preliminary analysis suggests distensibility (pressure – volume relation) declines with increased heart rate, even in healthy young adults, whereas augmentation index declines.