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Peripheral administration of obestatin reduces food intake and suppresses body weight gain in lean mice and rats
Author(s) -
Lagaud Guy Jean,
Young Brian,
Morton Magda,
Barrett Terrance,
Shankley Nigel
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb84-d
Subject(s) - obestatin , ghrelin , endocrinology , medicine , food intake , body weight , weight gain , hormone
Obestatin was recently described as a bioactive peptide encoded for by the same gene as ghrelin but with opposite actions on food intake (Zhang et al., 2005). Although some groups confirm these findings others report no effect of obestatin. We investigated the effect of obestatin over a wide range of doses for effects on feeding in rodents. Acute administration of obestatin produced significant inhibition of feeding at doses of 10–100 nmol/kg i.p. in mice. Interestingly, the dose‐response relationship was U‐shaped such that both low (0.01–3 nmol/kg) and high (1–3 μmol/kg) doses were without effect. Doses of 100–300 nmol/kg also suppressed feeding in lean and Zucker fatty rats. Treatment of mice with obestatin over a seven‐day period decreased body weight gain and food consumption. Consistent with the original report, obestatin suppressed food intake and body weight gain in rodents. The unusual dose‐response relationship may explain the difficulties in reproducing the effects of obestatin on feeding.