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Carcinocytotoxic Activity of the Yellow‐Lipped Sea Krait (Laticauda colubrina), Wagler’s Pit Viper (Tropidolaemus sp.) and Philippine Cobra (Naja philippinensis ) Venom
Author(s) -
Atanacio Ronald Comedia,
Escarlos Juliana Atanacio,
Escarlos Jose Atanacio,
Malbas Fidelino Fernandez,
Josefina Geronimo Garcia,
Atanacio Clemente Comedia,
Bautista Jack Anthony Estrada,
Buag Julie Cavo
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb79-a
Subject(s) - venom , cytolysis , naja , biology , ophidia , cobra , toxicology , cytotoxicity , biochemistry , in vitro , computer science , programming language
Cytotoxicological assay of the venom samples showed that crude Laticauda colubrina was the most lymphocytotoxicity, but the degree of lymphocytotoxicity was comparatively higher against leukemic lymphocytes than normal lymphocytes. Complete cytolysis of Hep 2 cells, Rhadomyosarcoma cells, and normal lymphocytes was observed in response to Tropidolaemus sp. and Naja philippinensis venom. Fractions of the Laticauda colubrina venom (Lc‐1 to Lc‐31) showed that all isolates were lymphocytotoxic, but the Lc‐16 fraction exhibited lymphocytotoxicity in malignant lymphocytes but not in normal lymphocytes. Lc‐16A, the first of the three peaks recorded in the HPLC profile of Lc‐16, showed the highest lymphocytotoxicity in leukemic lymphocytes.