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PPARγ2 Pro12Ala Polymorphism is Associated with Coronary Artery Disease and Myocardial Infarction in Women
Author(s) -
Devaney Joseph Michael,
Lindsay Robert S.,
GordishDressman Heather,
Kaufman David J.,
Adenika Remi J.,
Andrews James A.,
Jang Gil J.,
Lindsay Joseph,
Pichard Augusto D.,
Satler Lowell F.,
Kent Kenneth M.,
Waksman Ron,
Howard Barbara V.,
Epstein Stephen E.,
Burnett Mary Susan
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb76-b
Subject(s) - medicine , myocardial infarction , coronary artery disease , odds ratio , allele , population , diabetes mellitus , obesity , incidence (geometry) , type 2 diabetes , endocrinology , cardiology , gastroenterology , genetics , biology , gene , physics , environmental health , optics
Peroxisome proliferator‐activated receptor‐γ (PPARγ) plays a role in adipocyte differentiation and function, which in turn influences the propensity to both obesity and type 2 diabetes, known risk factors for atherosclerosis. We genotyped a PPARγ2 variant (Pro12Ala) in a population of 609 individuals admitted for cardiac catheterization at the Washington Hospital Center. For confirmation, a second population (American Indians; n=3,723) enrolled in the Strong Heart Study was genotyped. After stratifying by race and gender, among Caucasian women (n = 147) odds of CAD at any age increased significantly with a copy of the Ala allele in the Pro12Ala position (OR = 4.07, 95% CI 1.465–11.290, p=0.007). In addition, the Ala alelle was associated with mycardial infarction (MI) in women (OR=3.154, 95% CI 1.354–7.348, p=0.008). For confirmation, a second population (American Indians; n=3,723) enrolled in the Strong Heart Study was genotyped. American Indian women carrying the Ala allele showed a higher incidence of MI (OR= 1.825, 95% CI 1.059–3.146 P=0.03). Caucasian women with the Ala allele of the Pro12Ala variant in PPARγ2 have a high risk of developing CAD, and both Caucasian and American Indian women are at increased risk of developing MI.