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Leukocyte adhesion and migration in a blood vessel‐ Effect on nitric oxide and ROS levels
Author(s) -
Lakshmanan Nisha,
Richardson Will,
Kavdia Mahendra
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb72-b
Subject(s) - peroxynitrite , nitric oxide , superoxide , adhesion , chemistry , reactive oxygen species , superoxide dismutase , endothelium , biophysics , immunology , microbiology and biotechnology , biochemistry , biology , oxidative stress , endocrinology , enzyme , organic chemistry
Adhesion of leukocytes on endothelium and subsequent migration into vascular wall is observed in many diseased conditions including diabetes, cardiovascular diseases and hypercholesterolemia. Upon activation, leukocytes release a burst of reactive oxygen species such as superoxide. This burst can reduce nitric oxide availability and increase the peroxynitrite formation through a diffusion limited reaction, thus affecting several functions of endothelial‐derived nitric oxide. In this study, we formulated a mathematical model to quantify the effect that leukocyte adhesion on a tissue containing blood vessel has on the concentration profiles of nitric oxide, superoxide, and peroxynitrite. The predicted local concentrations of nitric oxide, superoxide and peroxynitrite changed significantly with leukocyte adhesion and migration into the tissue. In addition, we present the results from levels of superoxide dismutase, and locations of leukocytes and levels of oxidative bursts. Migrated leukocyte cause a decrease in nitric oxide and has a effect on the smooth muscle cells. A comprehensive investigation in this manner would give an insight into parameters which change the most from normal to diseased conditions.