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More isoflavones in children compared to adults after soy intake
Author(s) -
Halm Brunhild H,
Ashburn Leslie A,
Franke Adrian A
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb59
Subject(s) - daidzein , glycitein , genistein , isoflavones , urine , medicine , urine sample , physiology , excretion , daidzin , urinary system , zoology , biology
The purpose of this study was to determine whether children experience a higher systemic exposure to isoflavonoids when consuming a body weight adjusted dose of soy compared to adults. 40 study participants were recruited from a local Waldorf school, including 21 children and 19 adults. After a baseline urine sample was collected, participants ate a body weight adjusted dose of soy nuts (15g/54.4 kg) and completed a 12‐hour urine collection. 19 children and 18 adults completed the protocol correctly. Children, compared to adults, showed a statistically significant (p < 0.05 by unpaired t‐test) higher urinary isoflavone excretion rate for daidzein (+39%), genistein (+44%), all non‐metabolites (daidzein+genistein+glycitein;+41%), and total isoflavonoids (+32%).Isoflavones are more bioavailable in children versus adults. Urine is an excellent medium to determine systemic isoflavone exposure in children due to its non‐invasiveness and high compliance, in particular, when collected overnight; it also allows evaluation of completeness of specimen collection.