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Inhibition of UVB‐Induced Skin Tumor Development in SKH‐1 Hairless Mice by Inositol Hexaphosphate (IP6)
Author(s) -
Kolappaswamy Krishnan,
DeTolla Louis J,
Williams Kendra A,
Shamsuddin Abulkalam M,
Vucenik Ivana
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb57-a
Subject(s) - hairless , skin cancer , skin tumor , carcinogen , chemistry , photosensitivity , broad spectrum , medicine , pharmacology , cancer research , cancer , carcinogenesis , biochemistry , physics , quantum mechanics , combinatorial chemistry
The incidence of non‐melanoma skin carcinoma (NMSC) has been steadily increasing worldwide due to exposure to UV radiation. Since naturally occurring IP6 has been proven as a broad‐spectrum anticancer agent, we investigated the protective effect of IP6 on incidence of UVB‐induced skin cancer in SKH‐1 mice. While the treatment group was receiving 2% IP6 in drinking water with UVB exposure (n = 15), the control group was exposed to UVB light only (n =15). Mice were fed with an IP6 deficient diet. A parallel pilot study was conducted to determine the efficacy of topical IP6, applied one hour prior to irradiation, in preventing the UVB‐induced NMSC. The mice were irradiated 3 times a week; starting at 1.5 kJ/m 2 dose with weekly increments of 1.5 kJ/m 2 , to a final dose 9.0 kJ/m 2 . At the end of 31 weeks, IP6 in drinking water significantly inhibited the rate of tumor formation. Tumor incidence was 5‐fold lower in the treatment group, while tumor multiplicity was about 4‐times lower in the IP6 treatment group compared to the control group ( p < 0.01). Topical application of IP6 also significantly ( p < 0.01) decreased tumor incidence and multiplicity. These findings indicate that IP6 can be a potent cancer preventive agent either orally and/or topically, against UVB‐induced skin tumors. Further studies to understand the underlying molecular mechanism are warranted.