A Positive Relationship Between Resting Energy Expenditure (REE) and Bone Resorption Markers in Obese Subjects

Many studies have reported a positive correlation between body size and bone density. A recent study showed a relationship between REE and bone mass (Afghani A ’05) that was stronger than body mass index. In the current study we have assessed the relationship between REE and bone resorption markers [pyridinoline (PYD), deoxypyridinoline (DPD)]. In addition, the relationship between REE and body weight, lean body mass (LBM), and total body bone mineral density (BMD) was examined. Postmenopausal women and older men (50–70 years of age; 85 ± 15 kg; n=25) were supplemented with Ca to meet the recommended levels (1.2 g /day) for one month prior to obtaining measurements. Urinary PYD and DPD were measured in both a spot sample and in a 24‐hour collection. A linear regression analysis was used to assess the relationship between REE and bone turnover markers and density. As expected, REE was positively correlated with BMD, LBM, and weight (p < 0.0001). Interestingly, we also found that REE was positively correlated with PYD (p < 0.05) and showed a trend with DPD (p < 0.10). It is possible that under conditions of adequate Ca intake, REE regulates small changes in bone turnover that ultimately influence bone mass. Supported by NIH AG12161