Premium
Changes on weight gain during pregnancy and insulin sensitivity among Mexican women
Author(s) -
De Haene Jessica,
Navarro Abigail,
Ramos Maria Abel,
Villalpando Salvador,
Hidalgo Maria del Rocio,
King Janet,
Casanueva Esther
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb54-a
Subject(s) - medicine , weight gain , insulin sensitivity , endocrinology , pregnancy , insulin , gestation , insulin resistance , body weight , biology , genetics
To evaluate changes in insulin sensitivity and weight gain, 70 pregnant women (<20 wks of gestation (wog), glucose tolerant), attending prenatal care at INPer, Mexico City, were studied. Weight and height were measured at 20, 24, 28, 32 & 36 wog. Fasting glucose (FGC) and insulin (FIC) concentrations were determined at 20 & 28 wog. Insulin sensitivity (HOMA) was estimated. Differences in wt. gain (20–40wog), FGC, FIC and HOMA (20–28 wog) were calculated. Changes in wt gain were positively correlated with changes in: FGC (r=0.292; p<0.015), FIC (r=0.239; p<0.048) and HOMA (r=0.248; p<0.040). Women with pregestational BMI <25 had significantly lower FGC @28 wog (86 vs 90 mg/dL, p<0.020); FIC@28 wog (5.85 vs 9.3 uU p<0.01) and HOMA @28wog (1.26 vs 2.15, p<0.01), than women with ppBMI ≥25. Our results suggest that wt. gain and ppBMI ≥25 influence FIC, FGC and HOMA values during the 2nd half of pregnancy. Supported by UCMexus and FUNSALUD.