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Elevated acylcarnitine (AC) concentrations are associated with lower physical composite scores (PCS) in hemodialysis (HD) patients
Author(s) -
Steiber Alison Leah,
Carder Jackie,
Buss Mary Lou,
Spry Leslie,
Hoppel Charles
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb43-b
Subject(s) - medicine , hemodialysis , carnitine , gastroenterology , albumin , etiology , endocrinology
The physical composite score of the SF36 is a measure of an individual’s perceived physical functioning. Acylcarnitine intermediates are a reflection of mitochondrial metabolism. The purpose of this study was to determine whether HD patients with high AC concentrations had lower physical functioning as measured by the SF36. This is a secondary analysis of baseline data from a clinical trial conducted in HD patients with PSC of less than 35, a free carnitine of less than 40mmol/L, and received HD 3 time a week. The AC was measured from plasma at baseline using HPLC/MS/MS; SF36 was conducted within 2 weeks of the plasma collection. SPSS vs 14.0 was used to analyze the data and significance was defined as p<0.05. 40% of the sample (n=38) were female, 88% were Caucasian, and 42% had diabetes. The mean age, albumin, mid‐arm muscle circumference and PSC were 71+12years, 3.8+0.3mg/dL, 26.1+5.0cm, and 28.5+7.6, respectively. PCS was correlated with the following AC concentrations: octanoyl (r=−0.5), lauroyl (r=−0.5), trans‐2‐dodecenoyl (r=−0.4), myristoyl (r=−0.4), palmitoyl (r=−0.6), and plamitoleoyl (r=−0.5), respectively. No differences were found between gender, etiology, ethnic group or SGA score in the correlated intermediates. These results indicate that as AC concentrations increase perceived physical functioning decreases in hemodialysis patients.