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Decrement of Body Fat and Hypolipidemic Effect of Geum japonicum in High Fat Diet‐induced Obese Rats
Author(s) -
Kang Soon Ah,
Paek Ji Hoon,
Lee SunJin,
Choi Sung Eun,
Cho KangJin
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb41-c
Subject(s) - medicine , endocrinology , triglyceride , hyperlipidemia , dyslipidemia , lipid metabolism , obesity , leptin , chemistry , cholesterol , biology , diabetes mellitus
Obesity is often related disturbances of lipid metabolism that lead to an increase in serum triglyceride and cholesterol concentrations, which are involved in the development of cardiovascular disease. The present study was undertaken to discover the effect of high dose of G. japonicum extract diet in rats fed a diet enriched in beef tallow, providing a large amount of saturated fatty acids and cholesterol. The purpose of this study was to investigate whether the addition of high and low dose of G. japonicum extract diet prevent the potential adverse effects on adiposity and dyslipidemia of this diet. We investigated the effects of G. japonicum on the lipid and leptin metabolism in rats fed high fat diet. To determine whether the G. japonicum may have the hyoplipidemic effects, 4 wk old Sprague Dawley male rats fed high fat diet for 6 wks to induce obesity, and subsequently orally fed G. japonicum for further 4 wk. Supplementation with G. japonicum resulted in a significant reduction of body weight gain and visceral fat mass. Adipocyte cell size was significantly reduced by G. japonicum. Serum triglyceride and leptin level was significantly reduced and serum HDL‐cholesterol level was significantly increased by G. japonicum. The present results suggest that G. japonicum supplementation is beneficial for the suppression of diet‐induced obesity and hyperlipidemia.