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Glycine reduce the oxidative stress in metabolic syndrome patients
Author(s) -
LozaRodriguez Hilda,
TorresRamirez Nayeli,
DiazFlores Margarita,
Cruz Miguel,
HernandezSaavedra Daniel
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb39
Subject(s) - tbars , oxidative stress , sod2 , metabolic syndrome , medicine , endocrinology , lipid peroxidation , dyslipidemia , glycine , type 2 diabetes , oxidative phosphorylation , placebo , diabetes mellitus , chemistry , biochemistry , superoxide dismutase , pathology , alternative medicine , amino acid
Metabolic syndrome (MetS) is described by a clustering of signs and symptoms often present on apparent healthy individuals. Atherogenic dyslipidemia, elevated blood pressure, elevated plasma glucose, prothrombotic state, and proinflammatory state are risk factors associated with MetS diagnosis. These interacting factors create metabolic disarrangements often associated with obesity and degenerative diseases as type 2 diabetes. Reactive oxygen species (ROS) from abdominal fat and uncontrolled glucose metabolism are contributing factors for oxidative stress, and consequent complications in MetS patients. We conducted a trial with 60 individuals diagnosed with MetS (ATPIII criteria) to evaluate glycine as a protector of oxidative stress. 30 individuals were randomly feed with glycine and 30 with placebo by 3 months. We analyzed lipid peroxidation (TBARS), as well the mitocondrial enzyme sod2 expression by real time RT‐PCR. Individuals treated with glycine shown a 25% decrease in TBARS, and no significant differences (p= 0.05) were observed in the placebo group. Furthermore, there was a 20% reduction in SOD specific activity on the glycine treated group which correlates with the decrease in sod2 expression. The sod2 gene expression is induced by oxidative stress, and such decrease indicates an appropriate oxidative balance after glycine use. These results suggest that glycine had an important role in balancing the redox status of MetS patients, protecting them from oxidative damage as showed by the decrease in TBARS. Supported by Fondo para Fomento de Investigacion (FOFOI), IMSS.