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The role of CARM1‐SWI/SNF coactivator complex in the regulation of transcription via controlling of histone code
Author(s) -
Choi Kyung Chul,
Choi Hyo Kyoung,
Kang Hee Bum,
Kim Han Cheon,
Wong Jiemin,
Yoon Ho Geun
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb33-b
Subject(s) - swi/snf , histone code , chromatin remodeling , smarca4 , histone , repressor , microbiology and biotechnology , nucleosome , chromatin , chromatin structure remodeling (rsc) complex , coactivator , histone methylation , histone h3 , biology , transcription factor , chemistry , genetics , gene expression , gene , dna methylation
Chromatin remodeling protein complex, SWI/SNF is important for transcriptional co‐activation through steroid receptors and other activators, co‐repression through factors like the retinoblastoma protein, Rb. SWI/SNF generates altered nucleosome dimer from mononucleosome and changes the supercoiling or closed‐circular plasmid chromatin. It also repositions histone octamers on mono‐ and polynucleosomal templates. Transcriptional activators or repressors may play an active role in recruiting these activities to discrete sites when needed to induce or shut off adjacent gene expression. We demonstrate that CARM1 and SWI/SNF complex is required for transcriptional activation via regulation of histone code, mK9‐H3. Furthermore, CARM1 and SWI/SNF complex plays an important role in exchange of histone code between acetylation and methylation of lysine‐9. It is concluded that knocking‐down of CARM1‐SWI/SNF complex decreased the recruitment of coactivators on D1 gene, resulting in the decrease of transcriptional activation. ∗ This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF‐2006‐331‐E00036) and (KRF‐2005‐042‐E00022).