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Estrogen protects aldosterone/NaCl‐induced hypertension in conscious rats
Author(s) -
Xue Baojian,
BadauePassos Daniel,
Johnson Alan Kim,
Hay Meredith
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb120-b
Subject(s) - endocrinology , medicine , aldosterone , estrogen , blood pressure , hormone , mineralocorticoid , chemistry
Previous studies from our laboratory have shown that there are sex differences in the development of aldosterone (ALDO)/NaCl‐induced hypertension. The present study was performed to determine which sex hormone is responsible for these sex differences. Male and female Sprague‐Dawley rats were infused subcutaneously with ALDO (0.75 μg/h, 28 days) and 1% NaCl was provided as the sole source of drinking fluid. Aortic blood pressure was measured by DSI ® telemetry. ALDO+1% NaCl‐treated male rats progressively developed hypertension (101.6±2.8 to 124.6±3.6, Δ23.2±3.7 mmHg, n=6) but blood pressures in females were not different from the control values (98.4±1.7 to 101.8±3.5, Δ3.4±1.4 mmHg, n=4). Gonadectomy augmented ALDO+1% NaCl‐induced hypertension in females (Δ17.1±2.3 mmHg, n=3) but had no effect in males (Δ20.9±2.2 mmHg, n=4). Moreover, systemic infusion of 17β‐estradiol (250 μg/day) totally blocked ALDO+1% NaCl‐induced hypertension in intact males (Δ‐1.5±2.4 mmHg, n=3). These results indicate that estrogen may play a protective role in the development of ALDO+1% NaCl‐induced hypertension. (Supported by NIH HL‐59676, HL‐62261, HL‐14388, and DK‐66086.)