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The Protective Effect of Propolis on Dimethylnitrosamine‐Induced fibrosis of the Liver in Rats
Author(s) -
Gergerlioglu hasan serdar,
Gulsen Murat T,
Koruk Mehmet,
bagci cahit,
sari ibrahim,
kocer emrah,
tarakcioglu mehmet,
savas m cemil,
kadayifci Abdurrahman
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb111-b
Subject(s) - propolis , liver injury , in vivo , alanine transaminase , liver fibrosis , aspartate transaminase , pharmacology , antioxidant , fibrosis , alanine aminotransferase , liver function , medicine , liver tissue , transaminase , chemistry , alkaline phosphatase , enzyme , traditional medicine , biochemistry , biology , microbiology and biotechnology
Propolis has been used in traditional medicine eager, and it has been reported to have several biological activities such as anti‐inflammatory, anticancer, antioxidant, antibiotic, and antifungal activities. In this study, we investigated the protective effect of propolis on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Liver tissues were examined histopathologically and liver enzymes were measured as indicators of liver function. Propolis (10 microg/kg daily for 4 weeks intraperitoneally) remarkably prevented this DMN‐induced liver fibrosis and inhibited the elevation of serum alanine and aspartate transaminase levels. In conclusion, these results demonstrate that propolis exhibited in‐vivo hepatoprotective and anti‐fibrotic effects against DMN‐induced liver injury and suggest that propolis may be useful in the preventing the development of hepatic fibrosis.