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Siguan acupuncture ameliorates experimentally‐suppressed gastrointestinal motility by loperamide administration in healthy volunteers
Author(s) -
Oh DalSeok,
Park Jieun,
Shin SeonHwa,
Choi SunMi,
Son ChangGue
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb111-a
Subject(s) - acupuncture , medicine , loperamide , crossover study , acupuncture point , gastroenterology , motility , diarrhea , pathology , placebo , alternative medicine , biology , genetics
Objectives: To investigate the effect of manual acupuncture treatment at Siguan (LI4 and LR3 bilateral) on the suppression of gastrointestinal motility. Methods: An open, randomized, sham‐acupuncture controlled, crossover study was conducted in accordance with the recommendations of the Declaration of Helsinki. Nineteen healthy male subjects were randomly allocated to two groups, for acupuncture at Siguan points or sham acupuncture. During inhibition of GI‐motility by administering loperamide (4 mg at 0 and 12 h of treatment), acupuncture was given at 0, 12, 24, and 36 h after taken 20 radiomakers. To evaluate the effect of Siguan‐acupuncture, radiograph was taken at 0, 6, 12, 24, 48 h. Two weeks of washout period later, two groups were treated as crossover manners. The affected GI‐motility was calculated by distribution of 20 radio‐markers at ileum, ascending, transverse, descending colon, sigmoid/rectum, and outside body weighing different values (1, 2, 3, 4, 5 or 6 points respectively) at given time points. Biological parameters, such as, CBC, blood pressure and defecations were monitored throughout experiments. Results: There were different distribution of radiomakers between Siguan and sham point treatment groups at 6, 12 and 48 h ( P < .0001, P < .0001, and P = .0304, respectively) in Cochran‐Mantel‐Haenszel statistics. Conclusions: Siguan acupuncture could be applied to the various patients having a syndrome related with suppressed GI‐motility.