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Effects Of Acute Exercise On Endothelium‐Dependent Vasodilation In Skeletal Muscle Arterioles And Feed Arteries
Author(s) -
Patrick Marcus P.,
Engelbrecht Marc A.,
Daniel Brian M.,
Spier Scott A.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb110
Subject(s) - vasodilation , dilator , medicine , sodium nitroprusside , endothelium , endocrinology , acetylcholine , skeletal muscle , microcirculation , nitric oxide , anatomy , cardiology , chemistry
The purpose of this study was to determine whether one bout of exercise enhances endothelium‐dependent vasodilator responsiveness in skeletal muscle arterioles and feed arteries. Male Sprague‐Dawley rats were divided into exercise (EX) and a control groups (SED). The EX group ran on a treadmill at 30 m/min (15 o incline) until exhaustion. First‐order (1A) arterioles and feed arteries (FA) were isolated from the soleus muscle, cannulated, and pressurized. Luminal diameter changes were determined in response to the endothelium‐dependent vasodilators, acetylcholine (ACh, 10 −9 – 10 −4 M) and histamine (HIST, 10 −10 – 10 −4 M), and the smooth muscle dilator, sodium nitroprusside (SNP, 10 −10 – 10 −4 M). Acute exercise enhanced vasodilation to ACh in 1A arterioles and tended to enhance dilation to ACh in feed arteries (p=0.09). Maximal responsiveness to ACh was increased in feed arteries of the EX group. Both sensitivity and maximal responsiveness to HIST was enhanced in 1A arterioles, but only maximal responsiveness to HIST was enhanced in feed arteries of EX rats. These data demonstrate that one bout of exercise enhances endothelium‐dependent vasodilation. Furthermore, it appears that the 1A arterioles from oxidative muscle are more sensitive to changes in endothelial function following a single bout of exercise than feed arteries. This enhanced endothelium‐dependent dilation may contribute to post‐exercise hypotension.