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Exercise training increases hepatic CEACAM1 expression
Author(s) -
Lee Abraham Doukwoo,
Ghosh Sumona,
AlShare Qusai Y,
Cicila George T,
Najjar Sonia M
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb108
Subject(s) - medicine , endocrinology , endurance training , insulin , regimen
The low expression level of hepatic carcinoembryonic antigen‐related cell adhesion molecule 1 (hCEACAM1), responsible for circulating‐insulin clearance, is associated with insulin resistance. The purpose of this study was to determine if hCEACAM1 expression would be increased and associated with altered glucose tolerance after training, and its training‐induced changes would depend on genetic factors. Two different inbred rat strains [DA & Copenhagen (COP)] were divided into control and training groups. Rats in the training group underwent a swim training regimen consisting of two 3‐hour long bouts separated by a 45‐min long rest period, 6 days/wk for 4 weeks. At the completion of the training, all rats underwent a glucose tolerance test where blood glucose levels were measured at 6 time points over a 75‐min interval following i.p. glucose injection (2g/kg BW). hCEACAM1 expression levels analyzed by Western blotting increased by 85% (P<0.05) in DA, but not in COP, rats after training. Improvement in training‐induced glucose tolerance was also greater in DA (58%, P<0.001) than in COP (25%, P<0.01). The results demonstrate that hCEACAM1 is upregulated with endurance training and may play a role in training‐induced improvement in glucose tolerance and the magnitude of training‐induced change in hCEACAM1 expression level is dependent on genetic factors. Supported by Ohio Challenge Fund