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Augmented working muscle glycerol turnover after short‐term endurance training in men
Author(s) -
Wallis Gareth A,
Friedlander Anne L,
Jacobs Kevin A,
Horning Michael A,
Fattor Jill A,
Wolfel Eugene E,
Lopaschuk Gary D,
Brooks George A
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.lb105-c
Subject(s) - glycerol , chemistry , endurance training , medicine , turnover , cycle ergometer , endocrinology , biochemistry , heart rate , management , blood pressure , economics
Muscle glycerol turnover was determined using [ 2 H 5 ] glycerol infusion in eight men at rest and during leg cycle ergometer exercise before (60 min at 45% and 65% VO 2 peak [45% Pre, 65% Pre]) and after (60 min at 65% of pre‐training VO 2 peak [ABT], and 65% of post‐training VO 2 peak [RLT]) 9 weeks of endurance training. While a small, but significant net leg glycerol release was seen during rest before and after training (−36±7 μmol/min), there was no significant net muscle glycerol exchange during exercise in 45% Pre, ABT or RLT. A significant net muscle glycerol release was observed during exercise in 65% Pre (−95±36 μmol/min). Substantial tracer‐measured leg glycerol turnover was seen during rest (uptake, release: 103±8, 140±11 μmol/min), and this was significantly increased during exercise in 45% Pre, ABT, and RLT (2.2–2.9 fold higher vs. rest). After training, tracer‐measured leg glycerol uptake was significantly higher during exercise at ABT and RLT (1.9–2.3 fold higher vs. 65% Pre). In summary, muscle glycerol turnover is substantially greater than net glycerol exchange, can be increased by exercise and further, working muscle glycerol turnover is augmented by endurance training.