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New synthetised tetrazoles and their antibacterial activity
Author(s) -
Kurteshi Kemajl,
Vejhapi Idriz,
Haziri Arben,
Govori Sevdije,
Ismajli Muharrem,
Muzaferovic Sefkija
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a998-d
Subject(s) - escherichia coli , chemistry , antibacterial activity , bacteria , combinatorial chemistry , nuclear chemistry , stereochemistry , biochemistry , biology , genetics , gene
We have investigated the antibacterial activity of new synthesized organic compounds tetrazoles 4‐hidro‐3‐(1H‐tetrazol‐5‐yl) chromen‐2‐on and second compound. 4‐phenylamino‐3‐‐(1H‐tetrazol‐5‐yl) chromen‐2‐on. Our investigation is directed toward their activity against, Escherichia coli and Clebsiella spp.,. Applying the disc method we measured diameters of the inhibition zone around discs which are previously wetted with DMF solutions of compounds, 5mg/ml, 3mg/ml and 1mg/ml. According to this results we may conclude that these new synthesized organic compounds Tetrazoles (4hidro‐3‐(1H‐tetrazol‐5‐yl) chromen‐2‐on and second compound. 4‐phenylamino‐3‐‐(1H‐tetrazol‐5‐yl) chromen‐2‐on ), expres high activity against two species of bacteria Escherichia coli and Clebsiella spp. New synthesized compounds tetrazoles (4hidro‐3‐(1H‐tetrazol‐5‐yl) chromen‐2‐on and second compound. 4‐phenylamino‐3‐‐(1H‐tetrazol‐5‐yl) chromen‐2‐on ) are more active against E. coli, than Clebsiella spp.