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Establishing inhibitory concentrations of novel formamide fungicides on fungi pertinent to medicine and agriculture
Author(s) -
Schwan Michaela,
Bobylev Mikhail
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a998-b
Subject(s) - fungicide , mode of action , formamide , formamides , moiety , chemistry , agrochemical , triazole , biology , pharmacology , toxicology , biochemistry , stereochemistry , botany , organic chemistry , agriculture , ecology
Formamides are a novel group of anti‐fungal drugs discovered by Bobylev et al. Formamides were designed as analogs of triazole fungicides where the triazolyl moiety is replaced with the formamide moiety. Despite being analogs, formamide fungicides differ from triazole fungicides in their biochemical mode of action. Specifically, it was found that the lead candidate N‐[1‐(2,4‐dichlorophenyl)‐4,4‐dimethylpent‐1‐en‐3‐yl] formamide (I) did not affect the sterol composition of fungi that were grown in the presence of inhibitory concentrations of I. The site and mechanism of the anti‐fungal action of novel formamide fungicides remains unknown. One of the ways to determine the biochemical mode of action of a new fungicide is to investigate the changes in secondary metabolite production by the affected organisms. In this work, inhibitory concentrations were established against a number of medicinal and agricultural fungal pathogens. These concentrations will be used in future projects to determine the changes in the secondary metabolic profiles of the affected fungi and ultimately to determine the biochemical mode of action of novel formamide fungicides. Development of fungicides that target different modes of action is vital to overcoming anti‐fungal resistance. The project is supported by NIH grant P20 RR016741 from the NCRR.