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Anapedesis, a Basic Principle of Biological Systems Organization: Applications to Leukocyte Traffic and Cell Therapy
Author(s) -
Moldovan Nicanor I.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a969-a
Subject(s) - progenitor cell , deformation (meteorology) , microbiology and biotechnology , cell , stem cell , biophysics , resilience (materials science) , neuroscience , mechanics , biology , biological system , nanotechnology , materials science , physics , genetics , composite material
In response to the obstacles that constrain their movement, biological objects at all scales (from molecules to organisms) display a so far unrecognized adaptive property: embodying in their own structure and behavior the ability to minimize the deformation‐induced damage, by coordinately changing the shape, recovering it and repairing during and/or after deformation. We called this universal principle ’anapedesis’ (Greek word for ’resilience’). Here we will present our experimental work on cellular anapedesis of leukocytes and stem/progenitor cells within capillaries, and in vitro during movement through pores of sizes smaller than their cross‐section. We identified several correlated phenomena explained by the anapedetic behavior: relationship between cell deformability and plasma membrane integrity; paradoxical increase in cell volume during squeezing; post‐deformation actin polymerization; integrative role of Rho‐class molecules across multiple deformation‐related cell properties. These findings have implications in understanding the dynamics of inflammatory cells traffic, stem/progenitor recruitment, and optimization of protocols for cell therapy after their administration in peripheral circulation.