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Two types of inactivity‐induced changes of the number of white blood cells in rats
Author(s) -
Shirato Ken,
Motohashi Norio,
Tanihata Jun,
Tachiyashiki Kaoru,
Tomoda Akio,
Imaizumi Kazuhiko
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a936-a
Subject(s) - basophil , eosinophil , white blood cell , monocyte , immunology , medicine , immunity , immune system , antibody , immunoglobulin e , asthma
Prolonged inactivity is known to induce the responses of physiological defense systems such as the hypothalamo‐hypophyseal‐adrenocortical axis, sympathetic nervous system, and immuno‐responsive systems. However, the effects of different types of inactivity on immuno‐responsive systems are still unknown. Therefore, the effects of two types of inactivity (immobilization: IMM and whole body suspension: WBS) on the number of white blood cells were studied in rats. Male adult rats were divided into the control and each inactivity groups to compare the number of total white blood cells, lymphocytes, monocyte, neutrophil, eosinophil, and basophil. Both IMM and WBS were maintained for 11 days. IMM markedly increased the number of total white blood cells, monocyte, neutrophil, and eosinophil in the 1st‐10th day, whereas WBS‐induced changes of the number of these cells were characterized by the presence of a lag phase followed by the significant increased actions. IMM did not change the number of basophil. However, WBS increased the number of basophil in the 1st‐8th day to 2.8–4.8 times, compared with the values of the control. Both IMM and WBS did not change the number of lymphocytes. These results show that WBS increase the number of natural immunity cells without changing acquired immunity cells, and there are different responses in the number of total white blood cells and natural immunity cells between IMM and WBS.