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Contraction of human mesenteric arteries from colorectal tumours to endothelin‐1
Author(s) -
GarciaVillalon Angel Luis,
Lavalde Maria,
Ferrero Eduardo,
Fernandez Nuria,
Monge Luis,
Salcedo Adely,
Hidalgo Manuel,
Dieguez Godofredo
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a903
Subject(s) - mesenteric arteries , contraction (grammar) , medicine , bradykinin , vasodilation , isometric exercise , endothelin receptor , endothelin 1 , coronary arteries , endothelium , artery , nitric oxide , anatomy , pathology , cardiology , receptor
To analyze whether the response to endothelin‐1 is altered in the arteries supplying neoplasias, mesenteric arteries supplying colorectal tumours and from a region far from the tumour in the same patients, or from patients without tumoural pathology, were dissected during surgery and cut in 2 mm long segments. The arterial segments were prepared for isometric tension recording in organ baths, and the response to endothelin‐1 and to the endothelium‐dependent vasodilator bradikinin was recorded. Endothelin‐1 (10 −10 –10 −7 M) produced concentration‐dependent contraction which was greater in arteries from colorectal tumours than in arteries from a region far from the tumour in the same patients, or from patients without tumoural pathology. This contraction was not modified by inhibitor of nitric oxide L‐NAME (10 −4 M) or the inhibitor of cyclooxigenase meclofenamate (10 −5 M) in the three groups of arteries. In precontracted arteries, bradykinin (10 −9 –10 −5 M) produced relaxation that was similar in all experimental groups. Mesenteric arteries supplying colorectal tumours are more responsive to endothelin‐1, and this is not due to alteration of endothelial function (Supported in part by FMMMA and FIS‐ PI050994 )