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Genetic Determinants Defined By Two Congenic Strains Of Dahl Salt‐Sensitive (S) Rats Are Distinguishable In Their Neuronal Responsiveness To Central Na+
Author(s) -
Huang Bing S,
Ahmad Monir,
Deng Alan Y,
Leenen Frans HH
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a901-a
Subject(s) - endocrinology , medicine , aldosterone , epithelial sodium channel , ouabain , chemistry , congenic , spironolactone , pharmacology , sodium , gene , biochemistry , organic chemistry
In Dahl S rats, enhanced Na + transport via aldosterone‐MR‐ENaC‐“ouabain” may contribute to increased Na + entry from blood into CNS and increased sympathetic responses to brain Na + . We assessed these 2 phenotypes in Lewis, Dahl S rats and two congenic substrains C10S.L16 and C17S.L2. On high salt, C10S.L16 and C17S.L2 exhibit similar CSF [Na + ]↑ but lower BP versus Dahl S rats. Only C10S.L16 showed attenuated sympathetic and pressor responses to acute and chronic icv infusion of Na + ‐rich aCSF.In Dahl S rats on high salt, hypertension was prevented by icv infusions of Na + channel blocker benzamil or MR blocker spironolactone, but CSF [Na + ]↑ was prevented only by benzamil. Thus in Dahl S rats genetic variants within the segment of Ch10 but not 17 may contribute to gain‐of‐function of central mechanisms determining neuronal excitability to CSF Na + . Increased Na + entry into the CSF and enhanced sympathetic responses to brain Na + are likely due to different genetic variants in e.g. components of aldosterone‐MR‐ENaC‐“ouabain”.