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Intra‐male Group Stress Increases Blood Pressure and Myogenicity in WKY Males, But Not in SHR Males
Author(s) -
Reho John J.,
Toot Jonathan D.,
Dunphy Gail,
Ely Daniel,
Ramirez Rolando J.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a900-a
Subject(s) - medicine , blood pressure , endocrinology , inflammation , blood vessel
Chronic stress is an important factor in the development of cardiovascular disease involving blood pressure, vessel responsiveness, and inflammation. To investigate this mechanism, intra‐male group stress (GS) was used to examine changes to systolic blood pressure (SBP), vessel responsiveness by changes in diameter to intraluminal pressure increases (myogenicity; MYO), and inflammation by C‐reactive protein (CRP) in adult SHR and WKY males. The hypothesis was that GS would increase SBP, mesenteric vessel MYO, and CRP in WKY compared to SHR males. Adult SHR and WKY males were housed together in a group environment (n=5/strain) or under a control condition (n=5/strain) for one month. Blood pressure was measured biweekly by tail cuff and mesenteric artery responsiveness was measured by a pressure arteriograph. WKY GS males showed a significant increase in SBP compared to WKY controls (151 vs. 139 mmHg, p<0.05), while SHR GS and control males showed no SBP differences (170 vs. 184 mmHg). WKY GS males showed a trend of increasing MYO compared to SHR GS males. Plasma CRP also showed an increasing trend in WKY (8%) compared to SHR GS males (not significant). SBP, MYO, and CRP did not significantly change comparing SHR GS to control males, while in WKY males there were overall increases in GS compared to controls. In conclusion, GS could increase SBP in normotensive animals through an increase in MYO of resistance‐sized arteries.