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Dynamic characteristics of sympathetic nerve activity response to electroacupuncture at Zusanli in anesthetized cats
Author(s) -
Kawada Toru,
Miyamoto Tadayoshi,
Li Meihua,
Kamiya Atsunori,
Sugimachi Masaru
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a883
Subject(s) - zusanli , baroreflex , anesthesia , ankle , medicine , electroacupuncture , blood pressure , heart rate , anatomy , acupuncture , alternative medicine , pathology
Although electroacupuncture (EA) at Zusanli acupoint (a lateral point below the knee joint) reduces arterial pressure via sympathoinhibition, dynamic nature of sympathetic nerve activity (SNA) response to EA remains unknown. If reflexes such as the arterial baroreflex compensate for the disturbance, the effect of EA would reduce in the lower frequency range where the baroreflex gain is high. In 5 anesthetized cats, SNA was recorded from the left renal sympathetic nerve. We inserted stainless steel needles to Zusanli acupoint and another point between the ankle and Achilles’ tendon. We delivered EA according to a binary white noise sequence (0–3 mA, 10 Hz, 0.5‐ms pulse duration) with a switching interval of 4 s for 30 min. The transfer function from EA to SNA was estimated in the frequency range from 0.0024 to 0.2 Hz (see Figure). The transfer gain increased slightly as the modulation frequency increased. The phase plot showed the out‐of‐phase characteristics between EA and SNA in the frequency range under study. The coherence value was above 0.7. These results indicate that EA can suppress SNA over a wide frequency range regardless of the presence of potential feedback regulations.