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Effect of a grape seed extract on blood pressure in subjects with pre‐hypertension
Author(s) -
Lu Bob,
Robinson Melissa
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a881-d
Subject(s) - blood pressure , medicine , ambulatory blood pressure , placebo , grape seed extract , prehypertension , blood lipids , nutraceutical , diastole , cardiology , traditional medicine , cholesterol , alternative medicine , pathology
The effect of a grape seed extract on blood pressure was examined in subjects with pre‐hypertension (JNC 7) i.e. systolic blood pressures between 120 and 139 mmHg and/or a diastolic pressure between 80 and 89 mmHg. They were randomized into a placebo group and an experimental group. The experimental group was given grape seed extract at a dose of 300 mg/day for 8 weeks. The extract was manufactured by Polyphenolics Inc. (Madera CA) and marketed as Meganatural ® ‐BP (Patent pending). Serum lipids and blood glucose were measured at the start of the study and at the end. The blood pressure was recorded using an ambulatory blood pressure monitoring device (Tiba Medical Inc) at the start of the treatment period and at the end. The results (mmHg) are summarized in the Table below. The serum lipids and blood glucose were unchanged. These finding suggest that the grape seed extract used in the present study lowers systolic blood pressure significantly in subjects with pre‐hypertension. It is suggested that this extract could be used as a nutraceutical as a part of a lifestyle modification program.