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Hypotensive effect of chronic tea consumption in male normotensive Sprague‐Dawley rats.
Author(s) -
Raji Ismaila Adebayo,
Banjoko Abimbola,
Ashaye Isaiah,
Adigun Solomon
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a879-d
Subject(s) - triglyceride , medicine , cholesterol , blood pressure , endocrinology , body weight , diastole , high density lipoprotein , total cholesterol , chemistry
The study investigated the effect of chronic tea intake (1.76 g/kg bwt/day/rat for 42 days) on blood pressure, body weight and blood lipid profile (total cholesterol, triglycerides, high density lipoprotein (HDL)‐cholesterol and low density lipoprotein (LDL)‐cholesterol levels). At the end of the study, the tea‐treated rats (n=6) had lower systolic (102.8±1.9 c.f. 111.8±1.6 mmHg; P<0.005), diastolic (86.3±2.0 c.f. 94.5±1.2 mmHg; P<0.006) and mean arterial (91.8±1.9 c.f. 100.4±1.3 mmHg; P<0.004) pressures compared to the controls (n=6; given normal drinking water). The tea‐treated rats also had lower levels of LDL‐cholesterol (43.5±5.0 c.f. 80.0±6.6 mg/100ml; P<0.001), but higher levels of HDL‐cholesterol (28.8±2.4 c.f. 21.5±1.4 mg/100ml; P<0.025) compared to the controls. The total cholesterol level, triglyceride level and mean body weight was similar in both groups. The result suggests that chronic tea intake lowers blood pressure; and furthermore, the reduction in LDL‐cholesterol level, coupled with a rise in HDL‐cholesterol level may account for the hypotensive effect.