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Chronic high‐salt diet reduces very low frequency blood pressure variability in stroke‐prone but not in stroke‐resistant rats
Author(s) -
Langager Amanda M,
Rotella Diane L,
Stauss Harald M
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a877-c
Subject(s) - blood pressure , medicine , stroke (engine) , endocrinology , spontaneously hypertensive rat , mechanical engineering , engineering
In previous studies we demonstrated that myogenic vascular function specifically affects very low frequency (VLF, 0.02–0.2 Hz) blood pressure variability (BPV) in rats. In addition, impaired cerebrovascular myogenic function has been associated with hemorrhagic stroke in stroke‐prone spontaneously hypertensive rats (SHR‐SP) on high‐salt diet. Therefore, we hypothesized that VLF BPV is reduced in SHR‐SP on high‐salt diet but not in stroke‐resistant spontaneously hypertensive rats (SHR‐SR) or normotensive Wistar Kyoto rats (NT‐WKY). NT‐WKY (n=9), SHR‐SR (n=14), and SHR‐SP (n=13) received a high‐salt diet (1% NaCl in drinking water) for 4 or 6 weeks before arterial blood pressure was recorded in conscious animals. Blood pressure values at the 4 th and 6 th week of high‐salt diet were greater in SHR‐SP than in SHR‐SR and greater in SHR‐SR than in NT‐WKY. From the 4 th to the 6 th week of high‐salt diet, VLF BPV tended to increase in NT‐WKY (from 9.1±2.2 mmHg 2 to 13.5±6.4 mmHg 2 , not sig.) and SHR‐SR (from 14.6±1.4 mmHg 2 to 21.6±2.0 mmHg 2 , not sig.). In contrast, VLF BPV significantly decreased during this time period in SHR‐SP (from 20.2±2.8 mmHg 2 to 11.8±3.8 mmHg 2 , p<0.05). These data suggest that reduced VLF BPV indicates impaired myogenic vascular function in SHR‐SP on high‐salt diet prior to hemorrhagic stroke. Supported by: AHA #0630329N