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Effect of blood lipids on autonomic control in humans
Author(s) -
Monahan Kevin D.,
Dyckman Damian J.,
Ray Chester A.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a875-c
Subject(s) - baroreflex , blood pressure , medicine , isometric exercise , heart rate , sympathetic nervous system , autonomic nervous system , circulatory system , microneurography , hemodynamics , cold pressor test , cardiology , anesthesia
Increased blood lipids may detrimentally affect autonomic and circulatory control. We tested the hypothesis that acute elevations in blood lipids impair baroreflex control of cardiac period [cardiovagal baroreflex sensitivity (BRS)] and muscle sympathetic nerve activity (MSNA: sympathetic BRS) and augment pressor responses to physiological stress. BRS (modified Oxford technique) and neural (MSNA) and cardiovascular (blood pressure; BP) responses to isometric handgrip to fatigue (IHG) were determined before (Pre) and 60 min after (Post) beginning infusion of either Intralipid (0.8 ml/m 2 /min) and heparin (1000 U/hr) (experimental; n=12) or saline (0.8 ml/m 2 /min) and heparin (1000 U/hr) (control; n=6). BP increased modestly during infusion in experimental (p<0.05), but not control subjects. Cardiovagal BRS (19.8±1.8 vs. 19.1±2.4 ms/mmHg for Pre and Post, respectively), sympathetic BRS (−5.5±0.6 vs. −5.2±0.4 au/beat/mmHg), MSNA at rest (14±2 vs. 11±1 bursts/min), and responses to IHG were unchanged by infusion in experimental subjects (all p>0.05). Cardiovagal and sympathetic BRS, MSNA at rest, and IHG responses were unchanged (Pre vs. Post) in control subjects. These data do not provide support for the concept that acute increases in circulating blood lipids impairs BRS or augments physiological responses to IHG in humans. Support: NIH AG24420, HL77670, DC06459, M01 RR10732