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Relationship between sex hormones and coagulation‐fibrinolysis system in postmenopausal women with coronary heart disease
Author(s) -
Yang ZhiMing,
Kang∗ YuMing,
Liang Bin,
Yang HuiYu,
Zhang NaNa,
Xiao ShiChuan
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a850-c
Subject(s) - fibrinolysis , estrogen , fibrinogen , medicine , plasminogen activator , coagulation , endocrinology , hormone , plasminogen activator inhibitor 1 , progestin , tissue plasminogen activator
The present study was undertaken to investigate the relationship between sex hormones and coagulation‐fibrinolysis system in postmenopausal women with coronary heart disease (CHD). Methods and Results: 42 postmenopausal women with CDH were assigned to the patient group, 40 postmenopausal women without CDH were assigned as non‐CHD group, and 30 healthy premenopausal women were selected as control. Estradiol (E2) was lower (P<0.05) in the patient group than other groups, but no difference in progesterone (P) and testosterone (T) among the three groups. Coagulation promoting factors such as fibrinogen (FIB), von Wilebrand factor (vWf) and plasminogen activator inhibitor (PAI‐1) were increased (P<0.05) in the patient group compared with other groups, and tissue‐type plasminogen activator (tPA) activity was decreased (P<0.05). FIB, vWf and PAI‐1 were negatively correlated with E2 (r=−0.246, −0.432, −0.369), t‐PA was positively correlated with E2 (r=0.581), and there was no relationship between T and vWF, FIB, tPA and PAI‐1. The decreases in E2 and t‐PA, and the increase in vWF were dangerous factors in CHD. Conclusions: Estrogen was lower in the patient group than other groups. The decrease of estrogen may upregulate the activity of coagulation system and inhibit the activity of fibrinolysis system, which may be one factor of low CDH morbidity in premenopausal women.