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To sleep or eat: what is the body choice?
Author(s) -
Martins Paulo José Forcina,
Tufik Sergio,
D’Almeida Vânia
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a840
Subject(s) - sleep deprivation , leptin , sleep (system call) , endocrinology , medicine , hormone , glycogen , glucagon , weight loss , food intake , homeostasis , energy homeostasis , obesity , circadian rhythm , computer science , operating system
Epidemiological studies have shown a negative relationship between daily sleep hours and body mass index. However, rats differ from humans, since their weight does not increase with sleep deprivation. In the present study our aim was to investigate the body weight homeostatic control of rats, assessing their feeding behavior, hormones and glycogen storage responses to sleep deprivation. Recently we have shown that sleep deprived rats receiving chow pellets have impairment in food access and therefore a liquid diet have been offered in order to solve this inconvenience. We found a mild body weight reduction despite an increased food intake during 96h of sleep deprivation by platform technique. Furthermore, liver glycogen, blood leptin and insulin were reduced while glucagon and norepinephrine concentrations were increased in this condition. After 24h of sleep recovery the majority of these changes was restored despite of low food intake. These data suggest that sleep deprivation increases the energy demand and consequently decreases body weight. Body weight decrease triggers hormonal changes to activate catabolism and increase food intake. The failure in recovering weight under hyperphagic behavior led us to propose that factors such as sleep seek or stress overlap the feeding drive avoiding the equilibrium in energy balance during sleep deprivation. Research Support: FAPESP CNPq and AFIP.