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Differential Effects of Nano‐scale Particles On Cardiovascular EndPoints In Mice
Author(s) -
Wingard Christopher J,
Cozzi Emily,
Henriksen Ruth Ann,
Lust Robert M,
Cascio Wayne E,
Devlin Robert B,
Van Scott Michael R
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a811-a
Recent studies have defined cardiovascular endpoints to evaluate effects of particulate exposure. Cardiovascular responses to ambient ultrafine particulate matter (UFP) were compared to equivalent mass doses of CeO 2 , Printex‐90 (P90) and multi‐walled carbon nanotubes (MWCNT). Mice were exposed to 100 μg of UFP, CeO 2 , MWCNT, or vehicle by intratracheal instillation. Blood samples were collected 24 hrs later for differential cell counts and fibrinogen levels. Aortas were isolated to evaluate vascular reactivity. In other animals, myocardial ischemia/reperfusion (I/R) injury was induced by 20 min of coronary ligation and 2 hrs of reperfusion. MWCNT increased the I/R injury by 10% while UFP increased I/R injury by 20%. CeO 2 had no effect on I/R injury. Only ambient UFP decreased total blood leukocyte counts in contrast, MWCNT induced a larger increase in plasma fibrinogen than ambient UFP. UFP increased platelet number and altered vascular reactivity to Ach. CeO 2 had no effect on vascular reactivity. MWCNT exposure augmented the constrictor response to 5‐HT and noradrenaline, but had no effect on endothelial‐dependent responses. Different nano‐scale particles exert unique effects on ischemic injury and thrombogenic potential based on their composition and shape. This abstract of a proposed presentation does not necessarily reflect EPA policy. Funding support impart by Phillip Morris US and International.