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Elevation in serum IL‐6 is responsible for the vascular inflammation in arteries from diabetic patients
Author(s) -
Tejerina Teresa,
Redondo Santiago,
Ruiz Emilio,
GordilloMoscoso Antonio
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a803-c
Subject(s) - medicine , diabetes mellitus , coronary artery disease , inflammation , coronary arteries , type 2 diabetes mellitus , artery , disease , type 2 diabetes , c reactive protein , gastroenterology , cardiology , endocrinology
Background: Inflammation is a common feature in the majority of cardiovascular disease, including Diabetes Mellitus. We have previously reported that Cyclooxygenase‐2 (COX‐2) was highly expressed in internal mammary arteries from diabetic patients with atherosclerosis. Aim: The aim of this study was to evaluate the contribution of the systemic inflammatory markers to the expression of COX‐2 in internal mammary arteries isolated from diabetic patients who underwent coronary‐artery bypass graft (CABG). Methods: Through a cross‐sectional design, patients who underwent CABG were recruited. Biochemical and clinical data were collected from the medical record and by blood testing. We also analyzed the serum levels of the inflammatory markers: IL6, TNFalpha and C‐reactive protein (CRP). Results: The bivariate analysis of the variables showed that IL‐6, but not TNFalpha or CRP, was positively correlated with the expression of COX‐2 in internal mammary arteries from patients (r2=0.862, P<0.001). Interestingly, we also found that serum levels of triglycerides (TG) and HDL were related with COX‐2 expression, whereas this association was not statistically significant (r2=0.119, P=0.11 and r2=‐0.123, P=0.16 for TG and HDL respectively). Conclusions: The data presented here might follow this line of evidence suggesting the role of other sources for inflammatory mediators different from glucose in type 2 diabetic patients. This work was funded by Fondo de Investigaciones Sanitarias FISS 01/0815 (Health Research Fund from the Spanish Ministry of Health) and by RECAVA. We thanks to the Cardiac Surgery Service, (Hospital Clínico San Carlos, Madrid) for providing us the internal mammary arteries