Premium
Reinforcement history determines the reinforcing effects of quinpirole in the rat
Author(s) -
Collins Gregory Thomas,
Baladi Michelle G,
Woods James Henry
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a782
Subject(s) - reinforcement , quinpirole , saline , psychology , agonist , anesthesia , developmental psychology , medicine , receptor , social psychology
These experiments were aimed at extending the finding that the D3‐peferring agonist, 7‐OH‐DPAT, maintained responding in rhesus monkeys with a history of cocaine‐reinforced responding, but not in all monkeys with a history of food‐reinforced responding (Psychopharmacol. 125:13–22). In the present experiments, the effect of reinforcement history on responding for quinpirole (QPRL) was examined in rats. In one set of studies rats were trained to self‐administer cocaine, remifentanil, ketamine, or liquid‐food (LF) under an FR1 schedule of reinforcement, and QPRL (0.01, 0.032, or 0.1 mg/kg/inj) was assessed as a substitute reinforcer during 1.5 hour sessions over 7 days. When cocaine history was provided, QPRL maintained robust responding with the highest rates at 0.032 QPRL. However, QPRL was generally no different than saline when responding was previously maintained by LF, remifentanil, or ketamine. A second set of studies assessed the type of cocaine history necessary to establish QPRL‐reinforced responding in rats initially trained to respond for LF. Two substitutions were used with rats returned to LF between substitutions. In the first substitution, either saline, 0.032 QPRL, response‐contingent, or non‐contingent cocaine were delivered. Following interpolated LF, a second substitution was carried out with only QPRL. Rats previously maintained with response‐contingent cocaine were now maintained by QPRL; all other rats failed to be maintained by QPRL. Thus, a response‐contingent cocaine history was necessary to establish the reinforcing effect of QPRL. Research supported by grants DA20669 and F013771 through NIDA