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The hallucinogen‐like effects of N,N‐dipropyltryptamine are mediated by 5‐HT 1A and 5‐HT 2A receptors in the mouse
Author(s) -
Fantegrossi William E
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a780-c
Subject(s) - antagonist , 5 ht receptor , serotonin , antagonism , hallucinogen , pharmacology , receptor , in vivo , chemistry , receptor antagonist , medicine , endocrinology , biology , biochemistry , genetics
Few studies have examined the effects of N,N‐dipropyltryptamine (DPT) in vivo . In these studies, DPT was tested in a drug‐elicited head twitch assay and in a conditioned head twitch assay in Swiss Webster mice. The effects of DPT were challenged with the selective serotonin (5‐HT) 2A antagonist M100907, the 5‐HT 1A selective antagonist WAY‐100635, and with depletion of central 5‐HT produced via the synthesis inhibitor p ‐chlorophenylalanine (PCPA). DPT elicited dose‐dependent effects in both assays, and the shape of the dose‐effect curves was biphasic. WAY‐100635 produced a parallel rightward shift in the dose‐effect curves, indicative of surmountable antagonism, but the antagonist effects of M100907 were functionally insurmountable. The contribution of 5‐HT 2A receptors, 5‐HT 1A receptors, and central 5‐HT in the mediation of these effects will be discussed. These studies supported by USPHS grants DA020645 and RR00165, and by the College on Problems of Drug Dependence.