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Effects of the hallucinogen DPT on operant behavior in mice
Author(s) -
murnane aeneas c,
Goeders James E,
Howell Leonard L,
Fantegrossi William E
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a780
Subject(s) - hallucinogen , serotonin , tryptamine , psychology , antagonist , pharmacology , 5 ht receptor , neuroscience , medicine , receptor
N,N‐dipropyltryptamine (DPT) is a drug with hallucinogen‐like effects belonging to the tryptamine superfamily of psychotomimetics. Numerous drugs belonging to this superfamily have been discovered or synthesized, and these compounds vary both in structure and in mechanism of action. In particular, their propensity to induce the release of or block the reuptake of monoamines varies with structure. To aid in the evaluation of the relationship between the structure of these compounds and their behavioral effects, mice were trained to discriminate DPT from saline. Dose dependent generalization of DPT in the presence and absence of the selective serotonin 5‐HT 1A antagonist WAY‐100635 and the selective serotonin 5HT 2A antagonist M100907 were evaluated. Furthermore, appropriate dosing of DPT was established by evaluating rate suppressant effects on a four component FR schedule of food reinforcement. Finally, the duration of action was evaluated by measuring the reestablishment of behavioral output across the same schedule when a single injection of DPT was administered prior to the session. Subsequent studies will evaluate the contribution of structure to the behavioral effects of the tryptamines by measuring the generalization of other members of this superfamily to the DPT cue. These studies supported by USPHS grants DA020645 and RR00165, and by the College on Problems of Drug Dependence.