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Estradiol has protective effects on female growth restricted offspring in a model of programmed hypertension.
Author(s) -
Ojeda Norma B,
Grigore Daniela,
Robertson Elliott B,
Alexander Barbara T
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1417-c
Subject(s) - offspring , medicine , endocrinology , estrogen , intrauterine growth restriction , blood pressure , mean arterial pressure , biology , pregnancy , heart rate , gestation , genetics
Placental insufficiency results in intrauterine growth restriction (IUGR) and sex differences in programmed hypertension. Female IUGR offspring become normotensive after puberty while adult male IUGR offspring remain hypertensive. Hypertension can be induced by ovariectomy (OVX) in adult female IUGR suggesting estradiol (E) may provide a protective status in female IUGR offspring. Thus, the purpose of this study was to substantiate the protective status of estradiol on blood pressure regulation in adult female IUGR offspring. Bilateral OVX or sham OVX (intact) and insertion of telemetry probe were performed at 10 weeks of age in female control and IUGR offspring. Mean arterial pressure (MAP) was measured by radio telemetry from 12 to 16 weeks. 17 B Estradiol (E2) was administered from 14 to 16 weeks of age by subcutaneous pellets, designed to maintain E2 concentration within physiological levels. MAP was significantly elevated following OVX in female IUGR offspring at 16 weeks of age (140±2 mmHg; P <0.05 vs. intact IUGR 116±3, control intact 117±4 and control OVX 118±1). By 16 weeks of age E2 lead to a greater reduction in MAP in OVX IUGR (104±3 mmHg; Δ36 mmHg) versus OVX control (97±2; Δ 21 mmHg). These results suggest estrogen provides a protective status in female IUGR offspring and suggests another mechanism in the etiology of sex differences in programmed hypertension. NIH HL074927.