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Effect of post myocardial infarction exercise training on myocardial remodeling
Author(s) -
Xu Xiaohua,
Wan Wenhan,
Wilson Bryan,
Li Ji,
Ji Lisa,
Zhang John Q
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1378-b
Our objective was to test the hypothesis that early exercise after myocardial infarction (MI) could alleviate myocardial remodeling and induce protective effect on morphology. We studied the changes in myocardial collagen content by picrosirius red staining (PSR), in matrix metalloproteinase (MMP)‐1, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 by real‐time PCR (RT‐PCR) and western blot in the non‐infarct left ventricles. Rats (7 wks old) were surgically induced MI and assigned to 3 groups (n=4/group): Sham (no exercise, no MI), SedMI (MI, no exercise), and ExMI (MI and exercise). Rats in ExMI exercised for 8 wks starting 1 wk post‐MI. Collagen content in ExMI (0.85±0.12%) was comparable to Sham (0.63±0.07%), but lower ( p <0.05) than SedMI (1.18±0.16%) although there was no difference ( p >0.05) in type I collagen gene expressions between ExMI and SedMI. The expression of TIMP‐1 decreased about 10 times in ExMI and about 15 times in SedMI compared with Sham at protein level, however, it increased 1.2 times for ExMI and 2.4 times for SedMI compared with Sham at gene expression level, respectively. There were no differences in MMP‐1 protein levels among the three groups. Our results suggest that post‐MI exercise training may attenuate left ventricular remodeling, and induce cardiac protection. Supported by NIH grant (HL074273).