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Effect of Post‐MI Exercise Training on Thyroid Hormone Receptor and Myosin Heavy Chain Gene Expressions
Author(s) -
Wan Wenhan,
Li Ji,
Ji Lisa,
Powers Anthony S,
Lao Shunhua,
Zhang John Q.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1377-c
Subject(s) - sed , medicine , endocrinology , ventricle , thyroid , hormone , myosin , chemistry , biochemistry
Thyroid hormone (T3) induces alteration of myosin heavy chain (MHC) α and β in myocardium. A significant decrease in serum T3 is observed in patients following MI. We investigated the effect of post‐MI exercise training on gene expressions of thyroid hormone receptor (TR) α and β, and MHC α and β in rats with MI. Seven‐week‐old rats were surgically induced MI (~40% infarct of left ventricle). Rats were assigned into three groups (n=4/group) including a sham‐operated control group (Sham), a sedentary group with MI (Sed‐MI) and an exercise group with MI (Ex‐MI). Ex‐MI rats exercised at 16m/min, 50min/d, and 5d/wk for 8 wks starting one week post‐MI. Real‐time PCR was performed to analyze gene expressions on myocardium of the non‐infarct left ventricles. The results showed that both TR‐α and ‐β mRNA in Sed‐MI group (2.0±0.11 and 1.58±0.11 folds compared to Sham) were significantly (p<0.05) high than that in Ex‐MI (1.12±0.35 and 0.69±0.18). There was no significant difference (p>0.05) in MHC‐α mRNA between Sed‐MI (0.43±0.06) and Ex‐MI (0.34±0.10) groups. MHC‐β mRNA in Sed‐MI (4.76±0.11) was significantly (p<0.05) higher than Ex‐MI (2.68±0.28). These results suggest that post‐MI training may attenuate TR and MHC‐β gene expressions in the non‐infarct LV. Supported by NIH grant (HL074273).