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Reduced Endothelium‐Dependent Dilation with Aging in Humans is Associated with Increased Abdominal Visceral Fat
Author(s) -
Edwards Lindsay M.,
Beske Stacy D.,
Eskurza Iratxe,
Silver Annemarie E.,
Southall Kara L.,
Benay Francoise J.,
Lawson Brooke R.,
Seals Douglas R.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1373
Subject(s) - medicine , abdominal obesity , brachial artery , waist , endocrinology , obesity , endothelium , overweight , visceral fat , subcutaneous fat , abdominal fat , cardiology , adipose tissue , blood pressure , insulin resistance
The roles of increasing total body and abdominal fat in age‐associated reductions in endothelium‐dependent dilation (EDD) are unknown. Study 1: EDD (brachial artery flow‐mediated dilation, FMD) was 48% lower in older (n=20; 56–71 yr) vs. young (n=19; 19–27 yr) non‐obese and obese adults. Stepwise multiple regression analysis showed that the age‐related decline in FMD was independently related to waist‐to‐hip ratio (WHR), a measure of total abdominal fat (TAF), but not to total body fat. Correcting for WHR abolished age‐associated differences in FMD. Study 2: FMD was inversely related to CT‐determined abdominal visceral fat (AVF) (r= −0.54, P= 0.0001), but not to TAF (r= −0.25, P= 0.15) or abdominal subcutaneous fat (ASF) (r= −0.04, P= 0.83) in 19 young (19–36 yr) and 17 older (50–75 yr) overweight/obese adults. Subgroups of young and older adults differing in AVF, but matched for TAF and ASF, showed age‐related differences in FMD (8.3±0.5 vs. 5.6±0.8 %, P<0.05). In contrast, no age‐associated differences in FMD were observed in subgroups of young and older subjects matched for AVF. The only intermediary factors related to both AVF and FMD were plasma total and LDL cholesterol. We conclude that reductions in EDD with aging in humans are related to age‐associated increases in AVF. Plasma cholesterol may be an important factor linking AVF and EDD with aging. Support: NIH AG025194 , AG013038 , AG006537 , AG022241 , and RR00051.