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Shear rates in the brachial and femoral arteries of swine
Author(s) -
Newcomer Sean C,
Bowles Douglas K,
Laughlin M Harold
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1369-c
Subject(s) - brachial artery , medicine , femoral artery , cardiology , blood flow , angiography , blood pressure , shear rate , lumen (anatomy) , anatomy , materials science , composite material , viscosity
Upright posture and bipedal locomotion may contribute to the heterogeneous shear rates previously reported in the brachial and femoral arteries of resting humans. The purpose of this investigation is to test the hypothesis that brachial and femoral artery shear rates are similar in quadrupeds. Brachial and femoral angiography with a femoral approach was performed in 5 anesthetized female Yucatan swine. Lumen diameter and blood flow velocity were measured using angiography and intravascular flow wires, respectively. Diameter and mean blood velocity tended (P = 0.1) to be greater in the femoral (0.34 ± 0.04cm, 9.50 ± 2.05cm/s) compared to brachial (0.29 ± 0.02cm, 6.87 ± 0.48cm/s) arteries. However, there was no significant difference in calculated shear rate between the brachial and femoral arteries (98 ± 10s −1 , 118 ± 31s −1 ). Similarly, heart rate (130 ± 9bpm, 131 ± 11bpm), systemic blood pressure (MAP: 77 ± 8mmHg, 80 ± 9mmHg) and limb blood pressure (MAP: 87 ± 10mmHg, 86 ± 9mmHg) were not significantly different during brachial and femoral measurements of shear rate. These findings support our hypothesis that shear rate in the brachial and femoral arteries of quadrupeds are similar during rest. More importantly, our current data supports the hypothesis that upright posture and bipedal locomotion contribute to differing shear rates in the brachial and femoral arteries of humans. Supported by: RR 18276, AR 048523, HL 36088, HL 52490