OBESITY MEDIATED HYPERTENSION WHILE ALCOHOL MISUSE DECLINED RENAL ENDOTHELIAL BARRIERS OF WOMEN.

Two female study groups were compared in follow (n=248). Women with obesity were selected (A‐99: n=17, 33±3 kg/m2, aged 35±15 years, B‐04: n=14, 32±2 kg/m2, aged 36±11 years) and those tended to have normal fasting blood glucose. The original obesity group showed dyslipidemia and often reported alcohol misuse (56% out of A‐99) while the recent group showed normal lipid profiles and reported less often alcohol problems (10% out of B‐04) but more often smoking (40% out of B‐04 vs 6% out of A‐99). Both obesity groups showed a significant rise of blood pressure (p<0.05) while only the original obesity group tended to have proteinuria and/or hematuria (30% out of A‐99 vs none out of B‐04). Next, multivariate modelling was used of women selected by obesity and overweight (68 out of 248). Women with alcohol misuse showed significantly raised body weight (p=0.011). Smoking and raised body weight were also related (p=0.1). The data showed that obese women recently drank less and more often smoked probably to reduce body weight. Some benefit of food and alcohol counselling was recently found here but a direct harm of alcohol use on renal endothelial barriers remained. Obese women had significantly raised blood pressure with or without critical lipid profiles and/or lifestyle problems indicating that factors from the adipose tissue specifically mediated hypertension.