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Comparative genomic study of the α9 nicotinic acetylcholine receptor
Author(s) -
Lysakowski Anna
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1341-d
Subject(s) - turtle (robot) , biology , genbank , xenopus , vertebrate , hedgehog , fugu , zebrafish , nicotinic agonist , amino acid , zoology , genetics , gene , receptor , ecology
Our laboratory has recently cloned the turtle α9 nicotinic acetylcholine receptor (Genbank Acc. No. AY768813 ). Comparison to other published and Genbank‐deposited α9, α10, and α7 amino acid sequences allows us to draw several interesting conclusions. The species examined in this study were from several different vertebrate classes (mammalian: human, chimp, rhesus, dog, pig, cow, elephant, hedgehog, guinea pig, rat, mouse, oppossum; avian: chick, zebrafinch; reptilian: turtle; amphibian: xenopus; and fish: fugu, trout, zebrafish, and tetraodon). PROSITE analyses were done and allowed us to contrast and compare α9, α10, and α7 amino acid sequences. These comparisons show that the turtle sequence is similar to other published sequences, yet it displays some characteristics that may reflect its uniquely reptilian (or saurian) origin. Because few turtle genes have been cloned to date, however, the turtle may have unknown variations on the typical post‐translational modification sites found in mammals and fish. Support by NIDCD R01 DC02058 and R01 DC02521.